In addition to new endovascular
options for treating cerebral aneurysms, Aneuclose is also developing new
variations on surgical options. This work includes a patent-pending
"Vasospasm-Inhibiting Aneurysm Clip." Such a clip may prove useful
for inhibiting vasospasm and stroke from blood that leaks from a cerebral
aneurysm. It should be noted that this clip is currently only
in the developmental phase. Empirical research is required to ascertain
whether this clip is actually effective in inhibiting vasospasm and stroke.
This clip is not currently approved by the FDA for patient care.
Aneurysm Clip" is an implantable clip that is attached to the exterior
of an aneurysm or to the exterior of some other portion of a blood vessel
wall. This clip not only blocks blood from leaking from the vessel,
but it also elutes (or otherwise emits) an emitted substance to prevent
or treat vasospasm due to blood that has already leaked. For
example, this clip may elute magnesium. A magnesium-eluting aneurysm
clip can block the causal chain from cerebral aneurysm to ischemia and
stroke. Without requiring a larger tissue opening or additional
surgical time (since the neurosurgeon is already deploying a clip), a magnesium-eluting
aneurysm clip may not only stop blood from escaping out of the aneurysm,
but also help to prevent vasospasm from any blood that has already escaped.
A neurosurgeon may be able
to achieve long-term therapeutic levels of topical administration of magnesium
on the exterior of the affected vessels without the risk of a larger opening
or longer operation. This can be a considerable advantage over traditional
aneurysm clips, over intravenous or oral administration of calcium antagonists,
over short-term topical administration of calcium antagonists, and over
time-consuming insertion of multiple boluses of nimodipine in different
locations throughout the surrounding brain tissue.